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Year : 2021  |  Volume : 35  |  Issue : 3  |  Page : 118-121

COVID-19-associated Guillain‒Barre syndrome: Is it parainfectious or postinfectious?

Department of Medicine, Jawaharlal Nehru Institute of Medical Science, Imphal, Manipur, India

Correspondence Address:
M Ratankumar Singh
Department of Medicine, Jawaharlal Nehru Institute of Medical Science, Imphal, Manipur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jms.jms_6_22

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COVID -19 since its inception from the month of December 2019 has been associated with myriads of systemic complication apart from the respiratory failure, with Guillain-Barre syndrome (GBS) being one of the prominent neurological complication. More than 220 patients with GBS have been reported thus far. We wish to share 3 cases of GBS associated with COVID 19 admitted in our institute. GBS is one of the most common causes of acute, acquired weakness and is often provoked by a preceding infection, which triggers an immune response, cross-reacts with shared epitopes on peripheral nerve (molecular mimicry). Interestingly one of the cases developed limb weakness concurrently with the respiratory symptoms, probably during the viremic phase; the other 2 cases few weeks after recovering from COVID 19. So, is there a specific association with covid 19 and GBS? If associated, is it Para infectious or Post infectious? Further studies are needed to unravel its association with COVID 19.

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