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Year : 2017  |  Volume : 31  |  Issue : 2  |  Page : 90-93

Effect of palonosetron pretreatment to attenuate the pain caused by propofol injection

Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Takhelmayum Hemjit Singh
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.204817

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Objective: Propofol is the induction agent of choice in modern anesthetic practice because of its rapid onset, short duration of action, easy titration, and favorable side effect profile. Pain on injection of anesthetic is an important source of patient dissatisfaction and is a recognized adverse effect of propofol. We compared the effects of pretreatment of palonosetron and saline (placebo) in ameliorating propofol injection pain. Materials and Methods: Sixty adult patients of either sex (18–50 years, American Society of Anesthesiologists I and II) were randomized into two equal groups (n = 30) to receive either 1.5 ml of intravenous saline (placebo) or 1.5 ml of 75 mg palonosetron to compare the pain relieving effects of the drugs during propofol injection before the patients had lost consciousness. The propofol injection pain was assessed according to McCririck and Hunter scale. Results: The palonosetron group had significantly (P < 0.05) more patients (86.67%) without propofol injection pain as compared with the saline group (56.67%). Conclusion: Pretreatment with palonosetron with venous occlusion for 1 min can effectively reduce the incidence of propofol injection pain.

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