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Year : 2015  |  Volume : 29  |  Issue : 2  |  Page : 92-95

Priming effects of propofol during induction of anesthesia

Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Takhelmayum Hemjit Singh
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.163198

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Background: The "priming principle" is a method to reduce the total dose requirements of a drug. This study was carried out to evaluate whether the priming technique reduces the total induction dose requirements of propofol. Materials and Methods: Fifty (50) patients with American Society of Anesthesiologists (ASA) I and ASA II grades, of both sexes, aged 18-65 years, and undergoing elective surgical procedures under general anesthesia were randomly allocated into two equal groups with 25 patients each. Group I (control) received 3 mL of normal saline (placebo) intravenously (IV) as priming 2 min prior to the calculated dose of injection (inj.) propofol. Group II (study) received 0.5 mg/kg of inj. propofol as the priming dose 2 min prior to receiving a titrated dose of propofol. The titrated dose of propofol was given till loss of the eyelash reflex or loss of verbal command. Baseline hemodynamic variables were recorded at 2 min after priming and immediately after the titrated dose of propofol. Results: The hemodynamic changes in the heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) at different time intervals were similar in both groups (P > 0.05). The control group consumed a higher dose of inj. propofol (119.84 ± 12.28 mg) as compared with the study group (107.58 ± 14.73 mg), i.e., there was 10.23% reduction of the total dose in the study group. Most of the patients (80%) in both the groups were without any associated side effects and the incidence was similar (P = 1.00). Conclusion: The priming technique effectively reduced the total induction dose requirements of propofol and minimized periintubation hemodynamic alterations with minimal adverse effects.

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