| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 29
| Issue : 2 | Page : 92-95 |
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Priming effects of propofol during induction of anesthesia
Rilin Karlo, Nongthonbam Ratan Singh, Khullem Maniram Singh, Takhelmayum Hemjit Singh, Ningthoujam Anita Devi, Maharambam Binarani Devi
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India
Correspondence Address:
Takhelmayum Hemjit Singh
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-4958.163198
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Background: The "priming principle" is a method to reduce the total dose requirements of a drug. This study was carried out to evaluate whether the priming technique reduces the total induction dose requirements of propofol. Materials and Methods: Fifty (50) patients with American Society of Anesthesiologists (ASA) I and ASA II grades, of both sexes, aged 18-65 years, and undergoing elective surgical procedures under general anesthesia were randomly allocated into two equal groups with 25 patients each. Group I (control) received 3 mL of normal saline (placebo) intravenously (IV) as priming 2 min prior to the calculated dose of injection (inj.) propofol. Group II (study) received 0.5 mg/kg of inj. propofol as the priming dose 2 min prior to receiving a titrated dose of propofol. The titrated dose of propofol was given till loss of the eyelash reflex or loss of verbal command. Baseline hemodynamic variables were recorded at 2 min after priming and immediately after the titrated dose of propofol. Results: The hemodynamic changes in the heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) at different time intervals were similar in both groups (P > 0.05). The control group consumed a higher dose of inj. propofol (119.84 ± 12.28 mg) as compared with the study group (107.58 ± 14.73 mg), i.e., there was 10.23% reduction of the total dose in the study group. Most of the patients (80%) in both the groups were without any associated side effects and the incidence was similar (P = 1.00). Conclusion: The priming technique effectively reduced the total induction dose requirements of propofol and minimized periintubation hemodynamic alterations with minimal adverse effects. |
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