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Year : 2014  |  Volume : 28  |  Issue : 2  |  Page : 69-72

Effect of glycemic status on lung function tests in type 2 diabetes mellitus

1 Department of Physiology, Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
2 Department of Respiratory Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Dr. S N Naithok Jamatia
Department of Physiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.141071

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Background: Diabetes Mellitus is a metabolic disorder precipitating micro vascular, macro vascular complications and peripheral vascular diseases. Pulmonary complications of diabetes mellitus have been poorly characterized. Although some authors have reported normal pulmonary function, others found abnormalities in lung volumes, pulmonary mechanics, and diffusing capacity. Glycemic status have shown varied impact on lung functions. Objective: To measure lung volumes of type 2 diabetic patients and correlate with their glycemic status. Materials and Methods: Cross-sectional study was carried out among 30 type 2 diabetic patients and 30 age and sex matched non-diabetic controls in the Department of Physiology, Regional Institute of Medical Sciences (RIMS), Imphal. Spirometric recordings were estimated by using Computerized Spirometer-HELIOS 701. Blood glucose level was determined by glucose oxidase method and glycated hemoglobin (HbA1c) was estimated by using Glycohemoglobin HbA1-Test kit; Fast Ion-Exchange Resin Separation Method. Data was analyzed using Student's 't' test and Pearson correlation. Results: The pulmonary functions forced vital capacity (FVC), forced expired volume in one second (FEV 1 ), peak expiratory flow rate (PEFR) and forced mid-expiratory flow (FEF) 25-75% were decreased while FEV 1 /FVC was increased in the cases as compared to the controls. Lung functions exhibited rough negative correlation with post prandial blood sugar (PPBS) and HbA1c. Conclusion: The findings demonstrated modest albeit statistically significant impaired lung functions in restrictive pattern. The significant negative correlation between PPBS and FVC was seen. On correlating with HbA1c a significant negative correlation is seen with FVC and FEV 1 , suggesting that there is a definite association between the glycemic status and decreased lung function, but the exact pathophysiological mechanism to explain this association requires further research.

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