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Year : 2013  |  Volume : 27  |  Issue : 2  |  Page : 127-130

New-born screening for congenital hypothyroidism in Manipur by measurement of umbilical cord thyroid stimulating hormone: A hospital based study

Department of Physiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Rajkumar Arbind Singh
Department of Physiology, Regional Institute of Medical Sciences, Imphal, Manipur
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Source of Support: Financial assistance provided partly by RIMS, Imphal and partly by DBT Nodal Cell, Tezpur University, Assam, Conflict of Interest: None

DOI: 10.4103/0972-4958.121587

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Objective: The objective of this study was to determine the incidence of congenital hypothyroidism (CH) in neonates by measuring umbilical cord thyroid stimulating hormone (TSH), born in a Teaching Hospital in Manipur. Materials and Methods: The study was based on the findings from cord blood samples collected from 1,000 babies born to mothers having no systemic (especially thyroid disorders) and obstetrical complications in the last 2 years. Estimation of serum TSH level was carried out by enzyme-linked immunosorbent assay method using Eliscan TM (Diagnova) kit manufactured by Ranbaxy Fine Chemicals Ltd. (RFCL) India in the Department of Physiology, Regional Institute of Medical Sciences, Imphal. Results: The mean, median and standard deviation for the TSH values of the samples were 8.833 mIU/L, 6.824 mIU/L and 7.059 mIU/L respectively. Nearly, 29.3% of the babies had TSH greater than 10 mIU/L. One baby was found to be having CH out of the 1,000 screened. Conclusion: CH represents one of the most common preventable causes of mental retardation. The finding of 1 case of CH out of 1,000 new-borns screened indicates that incidence is high in this state. Screening of all new-borns in the future is highly recommended.

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