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Year : 2013  |  Volume : 27  |  Issue : 2  |  Page : 110-113

Co-induction effects of midazolam, thiopentone and ketamine with propofol in general anesthesia

Department of Anesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Gojendra Rajkumar
Department of Anesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.121578

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Objective: To evaluate whether the co-induction technique affects the total induction dose requirement of propofol and thereby reduce associated hemodynamic adverse effects. Materials and Methods: 120 american society of anesthesiologist (ASA) 1 and 2 patients undergoing general and gynecological surgeries under general anesthesia were randomly divided into four groups, i.e., group 1: Normal saline (control group), group 2: Midazolam, 0.03 mg/kg body weight, group 3: Thiopentone, 1 mg/kg body weight and group 4: Ketamine, 0.3 mg/kg body weight. After measuring the baseline hemodynamic variables and 2 min after study drug was given, propofol was administered 30 mg/10 s till the end points were reached -loss of verbal command or eyelash reflex. The total dose of propofol used and hemodynamic parameters were recorded following induction of anesthesia and the study was taken as completed and the rest of anesthesia proceeded as per standard technique. Results: Our study reveals that the total induction dose of propofol was reduced by 33.92% (group 2), 35.08% (group 3), and 42.69% (group 4) from that in the control group (group 1). The fall in mean arterial pressure from baseline in the midazolam (group 2), thiopentone (group 3) and ketamine group (group 4) was 10.88%, 14.58%, and 8.37% respectively. Conclusion: Ketamine reduced the induction dose requirement of propofol to the greatest degree and though, all three co-induction agents offered some degree of hemodynamic stability, ketamine provides the best cardiovascular stability.

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